Synaptic/cellular and microcircuit mechanisms of adaptive context encoding in the hippocampus

01/29/2020

Attila Losonczy¹

¹ Columbia University, New York, USA

The Losonczy lab used in vivo functional imaging of hippocampal microcircuits during associative learning tasks in mice dorsal hippocampus to identify and dissect the roles of identified hippocampal microcircuit elements – GABAergic interneuron subtypes and subcortical modulatory inputs – in learning-related plasticity and reorganization of hippocampal principal cells populations. I will discuss findings of how CA1 disinhibitory interneurons and catecholaminergic neuromodulation supports goal-directed spatial learning and related hippocampal place cell dynamics. Further, I will discuss how large-scale, unbiased imaging of hippocampal CA1 interneuron circuits and monosynaptically coupled interneuron-pyramidal cell subnetworks can provide insights into experience-dependent changes in hippocampal circuit dynamics. Finally, I will discuss hippocampal CA1 network dynamics supports aversive, temporal-associative learning.