ELECTROPHYSIOLOGICAL AND BEHAVIORAL PROPERTIES OF 4-AP INDUCED EPILEPTIC ACTIVITY IN MICE
4-aminopyridine is a convulsant that can induce epileptoid seizures. The aim of the present study was to investigate the in vivo the effect of intraperitoneally administered 4-aminopyridine in two doses (4 and 10 mg/kg) in mice. EEG, movement (accelerometer) and video recordings were made simultaneously in male B6 mice to specify the details of the seizures. Electrographic seizure escalation started earlier when the higher dose was administered and reached its peak earlier in both doses than behavioral activity. 4-AP in both doses induce an increase in alpha and beta activity bands that is in synchrony with the behavior and at 10mg/kg dose can enhance theta activity. This model is a reliable mouse seizure model that unlike pilocarpine model (Phelan et al., 2015), evokes electrographic seizure faster than behavior and evokes some of the symptoms listed in Racine scale.